Search results for "superparamagnetic iron oxide"
showing 7 items of 7 documents
Resovist enhanced MR imaging of the liver: Does quantitative assessment help in focal lesion classification and characterization?
2009
Purpose: To improve characterization of focal liver lesions by a prospective quantitative analysis of percentage signal intensity change, in dynamic and late phases after slow (0.5 mL/s) Resovist administration. Materials and Methods: Seventy-three patients were submitted on clinical indication to MR examination with Resovist. Signal intensity of 92 detected focal lesions (5–80 mm) were measured with regions of interest and normalized to paravertebral muscle in arterial, portal, equilibrium and T1/T2 late phases, by two observers in conference. Five values of percentage variations per patient were obtained and statistically evaluated. Results: The enhancement obtained on dynamic study is mo…
Functionalization of Metal and Carbon Nanoparticles with Potential in Cancer Theranostics
2021
Cancer theranostics is a new concept of medical approach that attempts to combine in a unique nanoplatform diagnosis, monitoring and therapy so as to provide eradication of a solid tumor in a non-invasive fashion. There are many available solutions to tackle cancer using theranostic agents such as photothermal therapy (PTT) and photodynamic therapy (PDT) under the guidance of imaging techniques (e.g., magnetic resonance—MRI, photoacoustic—PA or computed tomography—CT imaging). Additionally, there are several potential theranostic nanoplatforms able to combine diagnosis and therapy at once, such as gold nanoparticles (GNPs), graphene oxide (GO), superparamagnetic iron oxide nanoparticles (SP…
Synthesis of Titanate Nanotubes Directly Coated with USPIO in Hydrothermal Conditions: A New Detectable Nanocarrier
2011
International audience; Abstract: For the first time, titanate nanotubes (TiONts) coated with USPIO (ultrasmall superparamagnetic iron oxide) without polymer functionalization and directly obtained during TiONts formation is reported. The coating of these tubes was performed directly during the TiONts hydrothermal synthesis. After this treatment, in strongly basic conditions, USPIO particles kept their structure and magnetic properties while their size distribution slightly increased. By coupling zeta-potential measurements and TEM observations at different pH it appeared that interactions between nanotubes and USPIO were not electrostatic. This study presents the new design of a titanate n…
Silica-coated superparamagnetic nanoparticles as contrast agent for magnetic resonance imaging: Synthesis and physicological charaterizations
2015
Superparamagnetic iron oxide nanoparticles (SPIONs) have received a growing interest for various biomedical applications due to their interesting magnetic properties. Herein, we report a method for facile synthesis of colloidal silica-coated superparamagnetic iron oxide nanoparticles (Si-SPIONs). The polyvinyl alcohol (PVA)-SPIONs were successfully prepared and then coated with silica by the modified Stober method. The obtained Si-SPIONs are highly monodisperse with uniform morphology. Notably, comparing to uncoated SPIONs, silica coated ones show colloidal stability region at physiological pH which is applicable in biomedical applications and synthesis at the scale of grams was easily obta…
Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges
2021
International audience; Drug delivery and distribution in the central nervous system (CNS) and the inner ear represent a challenge for the medical and scientific world, especially because of the blood–brain and the blood–perilymph barriers. Solutions are being studied to circumvent or to facilitate drug diffusion across these structures. Using superparamagnetic iron oxide nanoparticles (SPIONs), which can be coated to change their properties and ensure biocompatibility, represents a promising tool as a drug carrier. They can act as nanocarriers and can be driven with precision by magnetic forces. The aim of this study was to systematically review the use of SPIONs in the CNS and the inner e…
Fast and continuous synthesis of nanostructured iron spinel in supercritical water: influence of cations and citrates
2014
International audience; Spinel iron oxide nanoparticles were obtained under supercritical water conditions in a continuous and fast (less than 10s) way by modifying the initial stoichiometric Fe II /Fe III molar ratio from (1/2) to (3/0), without base solution, and using citrates directly with iron precursors. This result opens the way of an economical and environmentally benign approach to synthesize superparamagnetic iron oxide nanoparticles (SPIONs) in important yields.
Advancing stem cells: New therapeutic strategies for treating central nervous system disorders
2018
In this special issue, we explore new methods and knowledge to improve stem cell transplantation in diseases and conditions such as stroke, PD, and depression. Advancing the conventional idea regarding cell replacement in stem cell therapy, stem cells may also transfer healthy mitochondria to diseased ischemic neurons in stroke and improve the therapeutic time window of tissue plasminogen activator (tPA) in a conjunctive therapy for stroke, and human Wharton’s Jelly-derived mesenchymal stromal cells (hWJ-MSCs) may rely mainly on trophic factor secretion to induce neuroprotective effects. In addition, trophic factors such as neurotrophin-4/5 (NT-4/5) and glial cell line-derived neurotrophic …